clinical trial · NCT05901714
A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam
Bristol-Myers Squibb·phase1·completed·n = 65
Healthy ParticipantsAfimetoranPhenytoinMidazolam
brief summary
This study will consist of 2 parts. The study will evaluate whether administration of phenytoin impacts the single-dose drug levels of afimetoran and BMT-271199 (Part 1) and will evaluate whether multiple administrations of afimetoran impact the drug levels of midazolam and 1-hydroxymidazolam (Part 2).
started
Jun 14, 2023
primary completion
Apr 11, 2024
completion
Apr 11, 2024
last updated
Aug 7, 2024
official title
An Open-label, Single-sequence, Drug-drug Interaction Study in Healthy Participants to Assess the Effect of Phenytoin on the Pharmacokinetics of a Single Oral Dose of Afimetoran (BMS-986256) (Part 1) and the Effect of Steady-state Afimetoran on the Pharmacokinetics of Midazolam (Part 2)
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol