clinical trial · NCT05552196
A Study of Ponesimod in Healthy Adult Participants
Janssen Pharmaceutica N.V., Belgium·phase1·completed·n = 28
HealthyPonesimodCarbamazepine
brief summary
The purpose of this study is to evaluate the effect of steady-state carbamazepine (CBZ; a strong pregnane X receptor \[PXR\] agonist) on the pharmacokinetics (PK) of ponesimod following a gradual up-titration regimen in healthy adult participants.
started
Oct 18, 2022
primary completion
Mar 5, 2023
completion
Mar 29, 2023
last updated
Apr 27, 2025
official title
A Phase 1, Open-label, Parallel-group Study to Assess the Effect of Steady-state Carbamazepine on the Pharmacokinetics of Ponesimod in Healthy Adult Participants
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol