clinical trial · NCT05402813
Natural History in Children up to 16 Years With Mild to Profound Hearing Loss Due to Mutations in GJB2 / OTOF Genes
Sensorion·—·recruiting·n = 180
Sensorineural Hearing Loss, BilateralAUNB1DFNB1ACongenital DeafnessDFNB9OTOF Gene MutationGJB2 Gene MutationPure Tone Audiometry AssessmentQuality of Life Questionnaires
brief summary
The purpose of this study is to follow the natural history of non-syndromic hearing loss caused by mutations in two genes (GJB2 or OTOF) in children up to 16 years of age.
started
Nov 18, 2022
primary completion
Nov 18, 2028
completion
Nov 18, 2028
last updated
Apr 6, 2026
detailed description
The study aims to:
* better describe the prevalence of cases of DFNB1A and DFNB9, including the type of mutations, and to assess the clinical course of the disease in children up to 16 years of age who have a mild to profound deafness. * better understand the audiological and genetic characteristics of the participants with congenital versus evolutive DFNB1A and DFNB9 deafness.
official title
Longitudinal Study of the Natural History of Two Autosomal Recessive Non Syndromic Deafness (DFNB1A and DFNB9) in Children up to 16 Years of Age
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol