clinical trial · NCT05329766
A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies
Gastrointestinal Tract MalignanciesDomvanalimabQuemliclustatZimberelimabFluorouracilLeucovorinOxaliplatin
brief summary
The purpose of this study is to evaluate the safety and preliminary clinical activity of treatment combinations with and without chemotherapy in participants with locally advanced unresectable or metastatic gastric, GEJ, and esophageal adenocarcinoma. Chemotherapy will consist of FOLFOX (oxaliplatin, leucovorin, fluorouracil).
started
Jun 10, 2022
primary completion
Jan 1, 2027
completion
Jun 1, 2027
last updated
Jul 2, 2026
official title
A Phase 2 Trial to Evaluate the Safety and Efficacy of Combination Therapies in Patients With Advanced Upper Gastrointestinal Tract Malignancies (EDGE-Gastric)
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol