clinical trial · NCT05277922
Effect of C21 on Forearm Blood Flow
Study Vasodilatory Effects of C21C21Sodium Nitroprusside
brief summary
The purpose of this study is to assess the effect of C21 on forearm blood flow by use of strain-gauge venous occlusion plethysmography.
started
Apr 28, 2022
primary completion
May 11, 2022
completion
May 18, 2022
last updated
Apr 23, 2025
detailed description
Subject will be screened for eligibility. Eligible subjects will receive ascending doses of C21 (3, 10, 30, 100, and 200 µg/min through local intra-arterial infusions for 5 min/dose. Forearm blood flow measurements will be performed in both arms during the last 2 minutes of each dose.
Infusions of sodium nitroprusside will be performed as a positive control using the same methodology.
official title
A Phase 1, Open-label, Single-centre Study Investigating the Effect of C21 on Forearm Blood Flow in Healthy Male Subjects by Use of Strain-gauge Venous Occlusion Plethysmography
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol