clinical trial · NCT02098460
To Compare the Effect of Concomitant Administration of Probucol and Cilostazol With Probucol Single Treatment on the Atherosclerosis Related Markers (Including the Thickness of the Achilles Tendon) and Evaluate Safety (Based on Atorvastatin Treatment) in Severe Hypercholesterolemia Subject
Otsuka Beijing Research Institute·phase4·completed·n = 300
Severe HypercholesterolemiaAtorvastatin, Probucol, Cilostazol
brief summary
To evaluate the effect of concomitant administration of Probucol and Cilostazol (based on Atorvastatin treatment) on the atherosclerosis related markers (including the thickness of the Achilles tendon) in severe hypercholesterolemia subject, through the observation of the thickness of the Achilles tendon, the thickness of mean carotid intima-media, anti-oxidation biomarkers and serum lipid profile.
started
Oct 1, 2013
primary completion
Mar 1, 2016
completion
Mar 1, 2016
last updated
Mar 27, 2025
detailed description
Multicenter, randomized, controlled, single-blinded, three parallel arms study. Group A: Atorvastatin + Probucol-placebo + Cilostazol-placebo Group B: Atorvastatin + Probucol + Cilostazol-placebo Group C: Atorvastatin + Probucol + Cilostazol
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol