clinical trial · NCT01606488
Effects of Brain Beta-Amyloid on Postoperative Cognition
University of California, San Francisco·phase4·active not recruiting·n = 66
Postoperative Cognitive DysfunctionFlorbetapir F 18 (18F-AV-45)no intervention
brief summary
Postoperative cognitive decline (POCD) affects up to 50% of non-cardiac surgical patients greater than or equal to 65 years of age. This study will test the hypothesis that preoperative presence of brain beta-amyloid plaques in non-demented subjects increases postoperative cognitive decline (POCD) in elderly subjects scheduled for hip or knee replacement. The investigators hypothesize that preoperative beta-amyloid plaques will predict postoperative cognitive decline.
started
May 1, 2012
primary completion
Jun 1, 2026
completion
Jun 1, 2026
last updated
May 1, 2025
official title
Effects of Brain Beta Amyloid on Postoperative Cognition and 18F-AV-45-A14: Clinical Evaluation of Florbetapir F 18 (18F-AV-45)
sourced from ClinicalTrials.gov · pharmadog mirrors structured fields, not the full protocol