Bicara CEO Claire Mazumdar to step down, COO Ryan Cohlhepp to assume leadership in 2027

Claire Mazumdar, who co‑founded Bicara and has served as its chief executive for almost seven years, announced she will step down at the end of the year. She will take parental leave and then move into a strategic advisor role and vice chair of the board.

The company’s chief operating officer, Ryan Cohlhepp, will succeed her as CEO on Jan. 1, 2027. Cohlhepp brings a decade of experience working with Mazumdar at Rheos Medicines and a long tenure at Takeda’s oncology division, where he held senior marketing, operations and analytics positions.

The leadership change comes as Bicara prepares for the potential market launch of its lead asset, ficerafusp alfa, a late‑stage bifunctional EGFR/TGF‑β therapy, positioning the new CEO to guide the company through this critical commercial phase.