<![CDATA[Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate Cancer]]>

Advertisement Opinion|Videos|May 13, 2026 Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate Cancer Author(s)Pedro C. Barata, MD, MSc, FACP , Johann de Bono, MD, PhD Dr. Johann De Bono and Dr. Pedro Barata discuss the increasing complexity of personalized treatment decision-making in metastatic castration-resistant prostate cancer (mCRPC) as radiopharmaceutical and targeted treatment options continue to expand. Advertisement Episodes in this seriesEP. 1 Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerEP. 2 Combination Radiopharmaceutical Approaches in Metastatic Castration-Resistant Prostate CancerEP. 3 Alpha-Emitting Therapies in Metastatic Castration-Resistant Prostate CancerEP. 4 Patient Selection for Radiopharmaceuticals in Metastatic Castration-Resistant Prostate CancerEP. 5 Treatment Sequencing in Metastatic Castration-Resistant Prostate CancerEP. 6 Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerEP. 7 Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerEP. 8 Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerNow PlayingEP. 9 Personalized Treatment Decision-Making in Metastatic Castration-Resistant Prostate CancerEP. 10 Future Directions in Metastatic Castration-Resistant Prostate Cancer Dr. Johann De Bono and Dr. Pedro Barata discuss the increasing complexity of personalized treatment decision-making in metastatic castration-resistant prostate cancer (mCRPC) as radiopharmaceutical and targeted treatment options continue to expand. Dr. Barata highlights the importance of integrating multiple clinical factors into treatment planning, including patient comorbidities, prior therapies, disease burden, metastatic distribution, PSMA expression, pathology, and molecular profiling. The faculty emphasize how genomic and imaging data are becoming increasingly important for selecting appropriate radiopharmaceutical approaches and optimizing sequencing strategies in mCRPC. The discussion also explores the growing number of emerging therapeutic targets beyond PSMA, including novel radioligand targets, antibody-drug conjugates, T-cell engagers, and additional targeted therapies that may further personalize care in the future. Together, the faculty underscore that treatment selection in mCRPC is becoming increasingly individualized, requiring integration of clinical judgment, biologic understanding, multidisciplinary collaboration, and evolving evidence to guide patient-centered decision-making in routine practice. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! Advertisement Related ContentAdvertisementFuture Directions in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Future Radiopharmaceutical Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Safety and Toxicity Management in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Combination and Sequencing Strategies in Metastatic Castration-Resistant Prostate CancerByPedro C. Barata, MD, MSc, FACP ,Johann de Bono, MD, PhDMay 13th 2026Treatment Sequencing in Metastatic Castration-Resistant Prostate CancerByPedro C. 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