<![CDATA[Sequencing Strategies After Progression in Multiple Myeloma ]]>

Opinion|Videos|May 12, 2026 Sequencing Strategies After Progression in Multiple Myeloma Author(s)Ajay K. Nooka, MD, MPH, FACP, Noopur S. Raje, MD, Surbhi Sidana, MD Episodes in this seriesEP. 1 Evolving Treatment Landscape in Relapsed and Refractory Multiple Myeloma EP. 2 Interpreting Emerging Data in Relapsed and Refractory Multiple Myeloma EP. 3 Key Factors Influencing Treatment Selection in Relapsed and Refractory Multiple Myeloma EP. 4 Treatment Sequencing Strategies in Relapsed and Refractory Multiple Myeloma EP. 5 Referral Timing and Access to Advanced Therapies in Multiple Myeloma EP. 6 Identifying Appropriate Candidates for Cellular Therapy in Multiple Myeloma EP. 7 Managing Toxicities and Supportive Care in Multiple Myeloma EP. 8 Balancing Clinical Trial and Real-World Evidence in Multiple Myeloma EP. 9 Choosing Among Treatment Options in Relapsed and Refractory Multiple Myeloma EP. 10 Functional High-Risk Versus Standard-Risk Multiple Myeloma EP. 11 Addressing Access Barriers in Relapsed and Refractory Multiple Myeloma EP. 12 Coordinating Care in Multiple Myeloma Across Practice Settings Now PlayingEP. 13 Sequencing Strategies After Progression in Multiple Myeloma EP. 14 Future Directions in Relapsed and Refractory Multiple Myeloma In this segment, Dr. Ajay Nooka engages the panel in a discussion on how to approach treatment sequencing for patients with relapsed and refractory multiple myeloma following disease progression. Dr. Noopur Raje and Dr. Surbhi Sidana share insights on how they evaluate available options, including novel agents and cell-based therapies, in the context of prior treatment exposure and disease trajectory. The panel discusses the importance of considering when to transition to a different therapeutic class versus continuing established regimens, emphasizing that this decision is influenced by factors such as response durability, disease aggressiveness, and patient-specific considerations. They also reflect on how emerging clinical data are shaping evolving sequencing strategies, particularly in earlier relapse settings. This segment highlights the complexity of treatment planning after progression and underscores the need for individualized approaches in managing multiple myeloma. NewsletterStay up to date on the most recent and practice-changing oncology dataSubscribe Now! 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