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STAT·1h ago·1 min read
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Definium's LSD pill shows significant anxiety reduction in Phase 3 trial

Aug 12, 2026·read at STAT ↗Positive readoutPositive

Definium Therapeutics announced results of a Phase 3 trial testing its LSD‑based pill DT120 in patients with generalized anxiety disorder.

The study enrolled 214 participants who received a single dose of DT120 or a placebo, and the company reported a statistically significant reduction in anxiety symptoms compared with placebo.

This is the first of two large trials planned for the anxiety indication and follows a recent Phase 3 success in major depression, underscoring the firm’s progress in psychedelic therapeutics.

The positive data may pave the way for further regulatory discussions and potential market entry, pending results from the upcoming trial.

source

This writeup was produced by pharmadog from original reporting by STAT.

Original headline: “STAT+: Definium Therapeutics says its LSD therapy eased anxiety in late-stage trial”

read at STAT ↗
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companies & drugs in this story

companies
Ultragenyx Pharmaceutical Inc.3NEUROCRINENEUROCRINE BIOSCIENCES INC
drugs
Rare Disease3
topics
Major Depression4Rare Disease3Gene Therapy (AAV)ImmunologyMonoclonal AntibodyPsychiatry & CNSVaccines

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