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Leader of Structure Biology and Protein Chemistry

Merck KGaA →Billerica, MA· posted Jul 7, 2026
R&D / Discovery

We are looking for a strategic leader to drive structural biology and protein chemistry initiatives, guiding a team of scientists across a diverse drug discovery portfolio. Lead programmes from target validation to clinical candidates, integrating structural and functional data. Ideal for experienced professionals with a strong background in drug discovery and team leadership.

requirements

Basic/Minimum Qualifications: • PhD in Structural Biology, Biochemistry, Biophysics, or a closely related field, with at least 10 years of relevant experience in the pharmaceutical or biotechnology sector. • Minimum 5 years of direct leadership or managerial experience of multiple reports, with a demonstrated ability to build, develop, and retain high-performing scientific teams. • Proven track record of delivering drug discovery programs from target validation through to clinical candidates, including Pre-IND or IND-enabling experience. • Hands-on expertise in the expression, purification, stabilization, and biophysical characterization of challenging protein targets, including membrane and soluble proteins. • Proficiency in Cryo-EM is essential. • Capabilities in at least one other structure determination technology, such as X-ray crystallography or nuclear magnetic resonance (NMR), with experience in hybrid or integrative structural approaches. • Record of high-impact publications demonstrating structural and mechanistic insights relevant to drug discovery. Preferred Qualifications: • Experience with emerging therapeutic modalities, including antibody-drug conjugates (ADCs), bispecific antibodies, PROTACs, or covalent inhibitors. • Established external network with academic institutions or industry partners to accelerate drug discovery programs. • Experience contributing to patent filings and intellectual property strategy based on structural biology findings. • Familiarity with modern data management, bioinformatics, and collaboration tools used in structural biology and drug discovery. • Strong verbal and written communication skills, with the ability to present complex structural data clearly to senior leadership and non-specialist stakeholders. Pay Transparency Pay Range for this position: $237,300.00 - $355,900.00 The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses. Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites. For more information click here. US Equal Employment Opportunities The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination. What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress! Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!

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