About Stoke:
Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit https://www.stoketherapeutics.com/
Position Purpose:
The Research Associate will support ongoing research efforts in designing and evaluating antisense therapies for diverse group of diseases. This position will report to a Scientist II in the Discovery Biology Group.
Key Responsibilities:
• Work in aseptic conditions and maintain cultures of various cell types.
• Screen and evaluate ASOs in relevant mouse tissues and cell-based assays.
• Perform cell and molecular biology techniques such as RNA, DNA and protein isolation, RT-PCR, RT-qPCR, ELISA and other project-specific assays, as necessary.
• Troubleshoot experiments, analyze and interpret data, participate in development of new assays with support from more senior scientists.
• Maintain accurate documentation of experiments in electronic lab notebook (ELN).
• Present research findings at group meetings.
• Other duties as assigned.
Required Skills & Experience:
• S with 2 years of post-graduate experience in molecular and cell biology research, preferably in industry or a Master’s degree in molecular or cellular biology.
• Strong background in cell culture including experience is required. Experience with transfection methods and neuronal cell culture is a plus
• Strong background in cell and molecular biology research; understanding of the basics of PCR is a must.
• Hands-on experience in RNA isolation techniques from cells and tissues, mammalian cell culture and cell-based assays is strongly desirable.
• Strong organizational and recordkeeping skills is a must.
• Ability to adapt to changing priorities and deadlines.
• Excellent planning and time management skills including the ability to support and prioritize multiple projects.
Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging Committee (DIB) underscores the importance of DIB to who we are and what we do.
Location(s):
This position is onsite in our Waltham, MA location.
Travel:
This position will require approximately 5% travel.
Compensation & Benefits:
At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.
The anticipated salary range for this role is $85,000 - $102,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.
Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP). Culture & Values:
At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.
Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.
Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:
https://www.stoketherapeutics.com/careers/
For more information, visit https://www.stoketherapeutics.com/.
All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.
Stoke participates in E-Verify.