Exciting opportunity for a Principal Scientist to provide scientific leadership in structural biology, focusing on macromolecular complexes and enabling structure-based design. Lead interdisciplinary projects, strengthen X-ray crystallography, and drive innovations in structural biology. Ideal for experienced professionals with deep expertise in high-resolution protein structure determination and a strong background in biopharma or biotech.
Principal Scientist (all genders) Structural Biology
requirements
• PhD in Structural Biology or a related field with 10+ years of relevant experience (including biopharma, biotech) and strong track record to design, execute and drive complex structural biology projects. • Deep expertise in high-resolution structure determination of proteins and protein complexes by Xray crystallography (sample generation, data collection & processing, structure refinement with industry-standard software). • Experience working with antigen–antibody and protein degrader complexes, with a deep understanding of structure–function relationships. • Ideally hands-on with single-particle cryo-EM and biophysical (e.g. HDX-MS, SAXS; Refeyn, FIDA, DSF) • Experience with cloud-based/HPC data management and processing; LINUX scripting; AI/ML-based prediction of biomolecular structures. • Effective collaborator and leader in multidisciplinary settings with excellent English communication; skilled in guiding/mentoring scientists, coordinating multi-site work, and managing CROs to balance project demands. • Proven ability to convey complex data clearly to drive decisions; strong publication history or impactful drug discovery contributions (oncology/immunology/neuroscience favored); excellent problem-solving abilities and experience introducing relevant new technologies. What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress! Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!