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drugs
WEZLANA

drug

WEZLANA

Marketedupdated 3mo ago

by $AMGN AMGEN INC

Approved

community read0 votes

🐶 often sniffed alongside

top 4

tagApproval24 co-mentions · 6 sources
drugustekinumab12 co-mentions · 6 sources
drugSTELARA12 co-mentions · 6 sources
company$AMGNAMGEN INC12 co-mentions · 6 sources

all catalysts(6)

approval · 6

$AMGN415.21-0.63%

WEZLANA (USTEKINUMAB-AUUB) — FDA approval

$AMGN415.21-0.63%

WEZLANA (USTEKINUMAB-AUUB) — FDA approval

$AMGN415.21-0.63%

WEZLANA (USTEKINUMAB-AUUB) — FDA approval

$AMGN415.21-0.63%

WEZLANA (USTEKINUMAB-AUUB) — FDA approval

$AMGN415.21-0.63%

WEZLANA (USTEKINUMAB-AUUB) — FDA approval

$AMGN415.21-0.63%

WEZLANA (USTEKINUMAB-AUUB) — FDA approval

News(0)

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brand

WEZLANA

generic

USTEKINUMAB-AUUB

MOA

12.1 Mechanism of Action Ustekinumab products are human IgG1κ monoclonal antibodies that bind with specificity to the p40 protein subunit used by both the IL-12 and IL-23 cytokines. IL-12 and IL-23 are naturally occurring cytokines that are involved in inflammatory and immune responses, such as natural killer cell activation and CD4+ T -cell differentiation and activation. In in vitro models, ustekinumab products were shown to disrupt IL-12 and IL-23 mediated signaling and cytokine cascades by disrupting the interaction of these cytokines with a shared cell-surface receptor chain, IL-12Rβ1. The cytokines IL-12 and IL-23 have been implicated as important contributors to the chronic inflammation that is a hallmark of Crohn's disease and ulcerative colitis. In animal models of colitis, genetic absence or antibody blockade of the p40 subunit of IL-12 and IL-23, the target of ustekinumab products, was shown to be protective.

phase

marketed

Data sources

openFDA · ClinicalTrials.gov

last refreshed 25m ago

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