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  1. pharmadog
  2. ›drugs
  3. ›Enhertu
drug · antibody drug conjugate
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trastuzumab deruxtecan

Marketedupdated 5mo ago
by Daiichi Sankyo Co Ltd🔗 ChEMBL
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • drugENHERTU78 co-mentions · 13 sources
  • tagApproval78 co-mentions · 13 sources
  • drugtrastuzumab39 co-mentions · 13 sources

Antibody drug conjugate drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 12 investigational indications.

indications

investigational
NSCLCColorectal Cancer

targets

Receptor tyrosine-protein kinase erbB-2DNA topoisomerase 1

all catalysts(13)

approval · 13
Dec 20, 2019
approval
7y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Jan 15, 2021
approval
6y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
May 4, 2022
approval
4y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
May 4, 2022
approval
4y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Aug 5, 2022
approval
4y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Aug 11, 2022
approval
4y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Nov 4, 2022
approval
4y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Feb 15, 2024
approval
3y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Apr 5, 2024
approval
3y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Jan 27, 2025
approval
2y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Jan 27, 2025
approval
2y ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Dec 15, 2025
approval
10mo ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
Dec 15, 2025
approval
10mo ago
ENHERTU (FAM-TRASTUZUMAB DERUXTECAN-NXKI) — FDA approval
trastuzumab deruxtecan
→
view all 13 catalysts →

Trials studying trastuzumab deruxtecan

  • phase2A Study of Patritumab Deruxtecan (HER3-DXd) in Combination With Trastuzumab Deruxtecan (T-DXd) in Participants With HR-Positive, HER2-Low or HER2-Ultralow Unresectable or Metastatic Breast Cancerrecruitingn=220
  • phase4Phase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian Patientsactive not recruitingn=100
  • phase2A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancerrecruitingn=1,132
  • phase2Trial of Trastuzumab Deruxtecan in Previously Treated HER2recruitingn=40
  • phase2Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)active not recruitingn=452
  • phase2TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXdrecruitingn=357
  • —DESTINY-PANTUMOUR04recruitingn=100
  • —A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)active not recruitingn=257

News(10)

  • STAT+: England to cover AstraZeneca breast cancer drug, a result of U.K.-U.S. drug pricing deal
    A breast cancer drug from AstraZeneca will now be available in England after a pricing deal was reached, in part a result of the U.S.-U.K. pharma pact.
    stat · 17d ago
  • WCLC ‘26: A new ‘ADC era,’ China questions and AstraZeneca’s spotlight
    The year’s biggest meeting on lung cancer research featured data suggesting a new treatment standard for an aggressive tumor as well as debate about the reliability of results from China-run studies.
    biopharma_dive · 19d ago
  • Electra aims for nearly $300M IPO; Enhertu's Phase 3 lung cancer success
    Plus news about Lilly, Cellectis, Tyra, Shennon and QL Biopharm. Electra Therapeutics eyes $297M IPO: The Sanofi-backed biotech hopes to kick off the post-Labor Day IPO train with a nearly $300 mil…
    endpoints · 20d ago
  • Unlocking cell surface protein research with site-specific labeling
    Applications in flow cytometry, cell sorting, target validation, and therapeutic discovery
    biospace · 21d ago
  • Genentech doubles down on ADC-resistant cancers with $1B DualityBio pact
    Roche’s Genentech is paying DualityBio $45 million upfront for rights to antibody-drug conjugates (ADCs) designed for the growing pool of patients who progress after treatment with the modality. Th…
    fiercebiotech · 1mo ago
  • Jazz scores front-line gastric cancer nod from FDA for ‘practice-changing’ Ziihera
    Gastroesophageal adenocarcinoma presents the biggest market opportunity for Jazz Pharmaceuticals’ Ziihera, according to Truist Securities, which forecasts peak sales of the drug to reach $2.5 billion.
    biospace · 1mo ago
  • AstraZeneca touts separate late-stage lung cancer wins with Tagrisso, Enhertu
    AstraZeneca on Monday reported successes in two late-stage trials in different forms of lung cancer — one with a two-drug combination of Tagrisso and Orpathys and another with its blockbuster antib…
    endpoints · 1mo ago
  • ‘Unlikely’ AstraZeneca-BMS mega-merger would be largest pharma deal ever
    If AstraZeneca and Bristol Myers Squibb were to successfully become one company, analysts say it could reset the current deal environment, which has picked up greatly in the first half of the year.
    biospace · 2mo ago
  • Daiichi’s pipeline falls behind rivals as cash flow nears peak: analysts
    With Enhertu and Datroway hitting their peak revenue and rivals flowing into the antibody-drug conjugate space, Jefferies cuts expectations for Daiichi Sankyo.
    biospace · 2mo ago
  • AstraZeneca execs ‘very confident’ in homegrown ADC pipeline despite scrapping 2 candidates
    AstraZeneca executives told Fierce they are “very confident” in the pharma’s in-house pipeline of ADCs despite scrapping two candidates that underperformed in the clinic.
    fiercebiotech · 2mo ago
view all news mentions →
brand
Enhertu
trade names
Enhertu
generic
fam-trastuzumab deruxtecan-nxki
MOA
Receptor protein-tyrosine kinase erbB-2 binding agent; DNA topoisomerase I inhibitor
indication
Metastatic Colorectal Cancer
phase
marketed
Data sources
openFDA · ClinicalTrials.gov · OpenTargets
last refreshed 2h ago
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