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  1. pharmadog
  2. ›drugs
  3. ›TEGRETOL
drug · small molecule
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TEGRETOL

updated 3mo ago
by $NVS NOVARTIS AG🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

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  • tagApproval784 co-mentions · 224 sources
  • drugTEGRETOL-XR729 co-mentions · 225 sources
  • drugcarbamazepine Teva393 co-mentions · 225 sources
  • drugCARBAMAZEPINE393 co-mentions · 225 sources
  • drugcarbamazepine ER393 co-mentions · 225 sources
  • tagSmall Molecule392 co-mentions · 224 sources
  • tagRecall1 co-mentions · 1 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 7 approved and 9 investigational indications.

targets

Sodium channel alpha subunit

all catalysts(0)

nothing on the calendar yet

Trials studying TEGRETOL

  • phase1A Drug-Drug Interaction (DDI) Study of Orforglipron With Carbamazepine in Healthy Participantscompletedn=30
  • phase1A Study to Evaluate the Effect of Food on the Single-Dose Pharmacokinetics and a Drug-Drug Interaction Evaluation of Itraconazole and Carbamazepine on INCB123667 When Administered Orally to Healthy Adult Participantsrecruitingn=51
  • phase1A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered Togetherrecruitingn=48
  • phase1Drug-drug Interaction Trial of AP31969 and Carbamazepine or Itraconazolerecruitingn=28
  • phase1A Study to Test the Effects of Itraconazole and Carbamazepine on OPC-167832 in Healthy Men and Womencompletedn=24
  • phase1A Study to Learn if Multiple Doses of the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine PF-07248144completedn=12
  • phase1To Assess the Enzyme Inducing Effects of Carbamazepine on the PK of Mirdametinib in Healthy Participantscompletedn=36
  • phase1A Study to Learn How Fluconazole, Carbamazepine and Itraconazole Affect How the Body Processes ASP3082 in Healthy Adultsrecruitingn=54
more trials →

News(0)

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brand
TEGRETOL
trade names
Arbil mr, Carbagen sr, Carbamazepine, Carbatrol, Carnexiv, Epimaz
generic
CARBAMAZEPINE
MOA
Mechanism of Action Tegretol has demonstrated anticonvulsant properties in rats and mice with electrically and chemically induced seizures. It appears to act by reducing polysynaptic responses and blocking the post-tetanic potentiation. Tegretol greatly reduces or abolishes pain induced by stimulation of the infraorbital nerve in cats and rats. It depresses thalamic potential and bulbar and polysynaptic reflexes, including the linguomandibular reflex in cats. Tegretol is chemically unrelated to other anticonvulsants or other drugs used to control the pain of trigeminal neuralgia. The mechanism of action remains unknown. The principal metabolite of Tegretol, carbamazepine-10,11-epoxide, has anticonvulsant activity as demonstrated in several in vivo animal models of seizures. Though clinical activity for the epoxide has been postulated, the significance of its activity with respect to the safety and efficacy of Tegretol has not been established.
indication
INDICATIONS AND USAGE Epilepsy Tegretol is indicated for use as an anticonvulsant drug. Evidence supporting efficacy of Tegretol as an anticonvulsant was derived from active drug-controlled studies that enrolled patients with the following seizure types: Partial seizures with complex symptomatology (psychomotor, temporal lobe). Patients with these seizures appear to show greater improvement than those with other types. Generalized tonic-clonic seizures (grand mal). Mixed seizure patterns which include the above, or other partial or generalized seizures. Absence seizures (petit mal) do not appear to be controlled by Tegretol (see PRECAUTIONS, General). Trigeminal Neuralgia Tegretol is indicated in the treatment of the pain associated with true trigeminal neuralgia. Beneficial results have also been reported in glossopharyngeal neuralgia. This drug is not a simple analgesic and should not be used for the relief of trivial aches or pains.
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 30m ago
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