drug

taliglucerase alfa

Marketedupdated 2mo ago

by $PFE PFIZER INC

Approved

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Enzyme drug with a maximum clinical stage of Approval (across all indications), with an approval for gaucher disease and metabolic disease and 1 investigational indication.

all catalysts(18)

approval · 18

May 1, 2012

approval

14y ago

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

ELELYSO (TALIGLUCERASE ALFA) — FDA approval

taliglucerase alfa

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brand

Elelyso

generic

taliglucerase alfa

MOA

12.1 Mechanism of Action Gaucher disease is an autosomal recessive disorder caused by mutations in the human glucocerebrosidase gene, which results in a reduced activity of the lysosomal enzyme glucocerebrosidase. Glucocerebrosidase catalyzes the conversion of the sphingolipid glucocerebroside into glucose and ceramide. The enzymatic deficiency results in accumulation of substrate glucocerebroside primarily in the lysosomal compartment of macrophages, giving rise to foam cells or "Gaucher cells," which accumulate in the liver, spleen and bone marrow. ELELYSO, an enzyme replacement therapy, is a recombinant analog of human lysosomal glucocerebrosidase that catalyzes the hydrolysis of glucocerebroside to glucose and ceramide, reducing the amount of accumulated glucocerebroside. ELELYSO uptake into cellular lysosomes is mediated by binding of ELELYSO mannose oligosaccharide chains to specific mannose receptors on the cell surface leading to internalization and subsequent transport to the lysosomes.

indication

Gaucher Disease Type I

phase

marketed

taliglucerase alfa

all catalysts(18)

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