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  1. pharmadog
  2. ›drugs
  3. ›Zegfrovy
drug · small molecule
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sunvozertinib

Marketedupdated 3mo ago
by Dizal Pharmaceutical Co Ltd🔗 ChEMBL
Approved
community read0 votes

Small molecule drug with a maximum clinical stage of Phase 3 (across all indications), with 3 investigational indications.

indications

investigational
NSCLC

all catalysts(0)

nothing on the calendar yet

Trials studying sunvozertinib

  • phase1A Multinational Study Assessing an Oral EGFR Inhibitor, DZD6008 in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN1)recruitingn=140
  • phase3A Study of DZD9008 Versus Platinum-Based Doublet Chemotherapy in Local Advanced or Metastatic Non-small Cell Lung Cancer (WU-KONG28)active not recruitingn=324
  • phase2Assessing an Oral EGFR Inhibitor, Sunvozertinib in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR or HER2 Mutation (WU-KONG1)active not recruitingn=315
  • phase2Study of Oral EGFR Inhibitor DZD6008 Combined With Sunvozertinib in Patients Who Have Advanced NSCLC With EGFR Mutations (TIAN-SHAN8)recruitingn=200
  • phase3A Phase 3 Study of Sunvozertinib Versus Placebo as Adjuvant Therapy in Patients With Early-Stage Non-Small Cell Lung Cancer Harboring EGFR Exon 20 Insertion Mutations or PACC Mutations After Radical Surgeryrecruitingn=360
  • phase2Perioperative Treatment of Sunvozertinib in Stage II-IIIB NSCLCrecruitingn=27
  • phase2Sunvozertinib (DZD9008) in Pretreated Lung Cancer Patients with EGFR Exon20 Insertion Mutation (WU-KONG6)active not recruitingn=104

Patent cliff

source: FDA Orange Book
first barrier falls
Jul 2, 2030
~3.9 years out

Earliest of all listed patents + FDA exclusivities. Generic / biosimilar entry typically only becomes possible AFTER both patent and exclusivity barriers expire.

patents (6)

  • Jan 28, 2039compositionUS 11007198
  • Jan 28, 2039compositionUS 11007198
  • Jan 28, 2039compositionUS 11504375
  • Jan 28, 2039compositionUS 11504375
  • Jan 28, 2039compositionUS 11896597
  • Jan 28, 2039compositionUS 11896597

FDA exclusivities (2)

  • Jul 2, 2030NCENew Chemical Entity (5y)3.9y
  • Jul 2, 2030NCENew Chemical Entity (5y)3.9y

News(8)

  • New Taiho, Cullinan data heats up lung cancer drug battle
    The findings position their drug, zipalertinib, as a threat to multiple approved medicines — while setting a bar for others in testing.
    biopharma_dive · 7d ago
  • Taiho and Cullinan’s zipalertinib clears Phase 3, teeing up first-line competition
    Taiho Pharmaceutical and Cullinan Therapeutics’ cancer asset is already under FDA review in a later setting, with a decision expected by February.
    biospace · 7d ago
  • Cullinan tees up J&J fight—and $100M payday—as Taiho-partnered drug hits phase 3 cancer goal
    Taiho Pharmaceutical and Cullinan Therapeutics have celebrated a second phase 3 victory for their small-molecule EGFR inhibitor, teeing up the partners to challenge Johnson & Johnson in a lung canc…
    fiercebiotech · 8d ago
  • J&J dips despite upbeat outlook; AstraZeneca, Spero cut China deals
    J&J’s shares ticked down as oncology sales missed expectations. Elsewhere, AstraZeneca bet $600 million on a lung cancer drug and a pair of biotechs snagged two of the year’s top venture rounds.
    biopharma_dive · 1mo ago
  • STAT+: Akero team, backed by Fairmount, launches new immunology company
    FDA approves injectable Leqembi, another post-Makary reversal, and other biotech news from The Readout
    stat · 1mo ago
  • AstraZeneca to take rights to Dizal's lung cancer pill Zegfrovy
    AstraZeneca is set to pay Dizal Pharmaceutical, which it part-owns, $600 million upfront for worldwide development and sales rights to the lung cancer drug Zegfrovy. The UK pharma said Tuesday that…
    endpoints · 1mo ago
  • OncLive Polls Reveal Picks for Top Lung Cancer Abstracts at ASCO 2026
    Lung cancer experts rank key abstracts of interest from the upcoming ASCO Annual Meeting on OncLive’s social media.
    onclive · 3mo ago
  • Track the Lung Cancer Abstracts That are Gaining Attention at ASCO 2026
    Read on to see what data are poised to shape clinical discussions and decision-making in lung cancer at 2026 ASCO Annual Meeting in Chicago, Illinois.
    onclive · 3mo ago
brand
Zegfrovy
generic
sunvozertinib
indication
Non-Small Cell Lung Cancer
phase
marketed
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 34m ago
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