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  1. pharmadog
  2. ›drugs
  3. ›Jakafi
drug · small molecule
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ruxolitinib phosphate

Phase 2updated 3mo ago
by $INCY INCYTE CORP🔗 ChEMBL
Phase 2
community read0 votes

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 5 approved and 6 investigational indications.

targets

Tyrosine-protein kinase JAK1Tyrosine-protein kinase JAK2

all catalysts(0)

nothing on the calendar yet

Trials studying ruxolitinib phosphate

  • phase2A Study to Evaluate Safety , Efficacy and Pharmacokinetics of WJ01024 Tablets Combined With Ruxolitinib in Patients With Myelofibrosisactive not recruitingn=33
  • phase3A Clinical Trial of Flonoltinib Maleate for Intermediate or High-Risk Myelofibrosisrecruitingn=105
  • EP1Pilot Study Using Changes in Serum BCMA to Determine Disease Progression in Multiple Myelomarecruitingn=30
  • phase1A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patientsrecruitingn=134

News(10)

  • Incyte cuts early-stage cancer drug to focus on next-gen programs
    Investors are focused on Incyte’s late-stage programs as the biotech braces for the 2028 patent cliff of its leading product Jakafi.
    biospace · 13d ago
  • Incyte ditches phase 1-stage JAK inhibitor to pursue next-gen options
    Incyte has ditched a JAK2 inhibitor in phase 1 development for a rare blood cancer in favor of “next-generation” replacements.
    fiercebiotech · 14d ago
  • Racing Takeda, InnoCare reports TYK2 inhibitor win in phase 2 vitiligo trial
    A phase 2 trial of InnoCare Pharma’s TYK2 inhibitor soficitinib in nonsegmental vitiligo has hit its primary endpoint, clearing the Chinese biotech to advance into the phase 3 part of the study.
    fiercebiotech · 26d ago
  • On second try, Acadia drug gets nod from European regulators
    The influential CHMP committee also threw its support behind more than a dozen other medicines while recommending the marketing authorization for Tavneos be revoked.
    biopharma_dive · 1mo ago
  • Lilly scores early positive data for new JAK drug
    Acquired through its purchase of Ajax, the drug showed encouraging effects in patients with hard-to-treat myelofibrosis. To analysts, such results could lead to competition for Incyte’s Jakafi.
    biopharma_dive · 1mo ago
  • Incyte CEO sees $2B Vega deal aiding a post-Jakafi future
    Bill Meury has been in or led the C-suite of several biopharma companies that have constructed multibillion-dollar exits over the past decade: Allergan, Karuna and Anthos. Now, he’s the one buying.…
    endpoints · 2mo ago
  • Incyte to buy blood disorder drug in possibly $2B deal
    Acquiring Vega Therapeutics, an offshoot of "hub-and-spoke" biotech Star Therapeutics, would give Incyte a medicine that’s in late-stage testing and designed to control bleeding.
    biopharma_dive · 2mo ago
  • Five Under 5: Top Oncology Videos for the Week of 5/3
    The top 5 OncLive TV videos of the week cover insights in ovarian cancer, classical Hodgkin lymphoma, pancreatic cancer, melanoma, and myelofibrosis.
    onclive · 3mo ago
  • Dr Kuykendall on the Evolving JAK Inhibitor and Transplant Considerations in Myelofibrosis
    Andrew Kuykendall, MD, explains considerations for JAK inhibitor sequencing and the use of transplant in myelofibrosis.
    onclive · 3mo ago
  • Lilly to buy startup Ajax in bid for a better JAK drug
    Worth up to $2.3 billion overall, the deal hands Lilly a drug designed to address the weaknesses of a class of medicines used to treat myelofibrosis and other diseases.
    biopharma_dive · 3mo ago
view all news mentions →
brand
Jakafi
trade names
Jakafi, Jakavi, Opzelura
generic
ruxolitinib phosphate
MOA
Tyrosine-protein kinase JAK1 inhibitor; Tyrosine-protein kinase JAK2 inhibitor
indication
Hemophagocytic Lymphohistiocytosis
phase
phase_2
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 6m ago
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