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  1. pharmadog
  2. ›drugs
  3. ›PLUVICTO
drug · protein
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PLUVICTO

updated 5mo ago
by $NVS NOVARTIS AG🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 4
  • tagApproval18 co-mentions · 5 sources
  • druglutetium Lu 177 vipivotide tetraxetan12 co-mentions · 5 sources
  • tagOncology4 co-mentions · 1 sources
  • tagProstate Cancer4 co-mentions · 1 sources

Protein drug with a maximum clinical stage of Approval (across all indications), with an approval for prostate cancer and 6 investigational indications.

targets

Glutamate carboxypeptidase 2

all catalysts(0)

nothing on the calendar yet

Trials studying PLUVICTO

  • phase1A Study of JNJ-87189401 Combined With JNJ-78278343 for Advanced Prostate Cancerrecruitingn=355
  • phase1A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancerrecruitingn=300
  • EP1A Dosimetry Study of Lutetium (177Lu) rhPSMA-10.1 and Lutetium (177Lu) Vipivotide Tetraxetan (Pluvicto®) in Patients With Non-curative Metastatic Prostate Cancerterminatedn=17

News(10)

  • 3 steps for taking on Novartis in radiopharma: Curium up first
    To successfully challenge Novartis on two planned fronts, Curium will need to overcome the unique challenges posed by radiopharmaceutical supply to get products to patients and win market share.
    biospace · 5d ago
  • Novartis bets up to $900M for radioligand therapy from China’s BoomRay
    Novartis is the current radiopharma leader with two FDA-approved therapies in Pluvicto and Lutathera.
    biospace · 10d ago
  • Novartis secures new radioligand in $900M deal as competition strengthens
    As an imposing new competitor begins to take shape, radiopharma leader Novartis has beefed up its pipeline by licensing a preclinical radioligand therapy from a specialist Chinese biotech.
    fiercebiotech · 11d ago
  • Western licensing deals for Chinese radioligand therapies to jump in 2027, Sleuth forecasts
    Deals for Chinese radiopharmaceutical assets have been rare to date and there is a limited pool of potential Western buyers available, Sleuth said.
    biospace · 12d ago
  • Sleuth forecasts 2027 jump in Western license deals for Chinese radioligand therapies
    Deals for Chinese radiopharmaceutical assets have been rare to date and there is a limited pool of potential Western buyers available, Sleuth said.
    biospace · 12d ago
  • Telix buys ITM for $1.65B in ‘supercritical’ radiopharma M&A
    Aside from its manufacturing and distribution footprint, ITM Isotope Technologies Munich will give Telix Pharmaceuticals the late-stage ITM-11, being developed for gastroenteropancreatic neuroendoc…
    biospace · 12d ago
  • Telix buys ITM in bid to create a ‘radiopharmaceutical powerhouse’
    Worth $1.65 billion up front, the deal combines two large pipelines and manufacturing networks, helping Telix potentially “corner the industry” for radiopharmaceuticals, one analyst wrote.
    biopharma_dive · 12d ago
  • Analysts ‘extremely bullish’ as Telix beams into Novartis’ territory with $1.6B ITM acquisition
    Telix has struck a deal to buy ITM Isotope Technologies Munich for $1.65 billion upfront, securing an R&D pipeline led by a rival to Novartis’ Lutathera and a radiopharmaceutical supply network.
    fiercebiotech · 13d ago
  • Novartis’ board faces investor scrutiny after M&A misfires and R&D flops
    Back-to-back failures of multiple late-phase trials have raised questions about how Novartis has deployed capital in pursuit of drugs to drive growth through the 2030s.
    biospace · 23d ago
  • A winner, a loser, and a mid-stage signal from a major cardiology research conference
    The mental health system after Lindsay Clancy, pushing boundaries for new radiopharmaceuticals, and more health news from Morning Rounds
    stat · 1mo ago
view all news mentions →
brand
PLUVICTO
trade names
Pluvicto
generic
LUTETIUM LU-177 VIPIVOTIDE TETRAXETAN
MOA
12.1 Mechanism of Action Lutetium Lu 177 vipivotide tetraxetan is a radioligand therapeutic agent. The active moiety of lutetium Lu 177 vipivotide tetraxetan is the radionuclide lutetium-177 which is linked to a moiety that binds to PSMA, a transmembrane protein that is expressed in prostate cancer, including mCRPC. Upon binding of lutetium Lu 177 vipivotide tetraxetan to PSMA-expressing cells, the beta-minus emission from lutetium-177 delivers radiation to PSMA-expressing cells, as well as to surrounding cells, and induces DNA damage which can lead to cell death.
indication
1 INDICATIONS AND USAGE PLUVICTO is indicated for the treatment of adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor pathway inhibitor (ARPI) therapy, and are considered appropriate to delay taxane-based chemotherapy, or have received prior taxane-based chemotherapy. PLUVICTO is a radioligand therapeutic agent indicated for the treatment of adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor pathway inhibitor (ARPI) therapy, and are considered appropriate to delay taxane-based chemotherapy, or have received prior taxane-based chemotherapy. ( 1 )
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 4h ago
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