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  1. pharmadog
  2. ›drugs
  3. ›OZURDEX
drug · small molecule
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OZURDEX

updated 3mo ago
by $ABBV AbbVie Inc.🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 5
  • tagApproval40 co-mentions · 20 sources
  • drugdexamethasone SR40 co-mentions · 20 sources
  • drugdexamethasone LA14 co-mentions · 14 sources
  • tagOphthalmology6 co-mentions · 6 sources
  • drug(dexamethasone + tobramycin)6 co-mentions · 6 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 75 approved and 174 investigational indications.

targets

Glucocorticoid receptor

all catalysts(0)

nothing on the calendar yet

Trials studying OZURDEX

  • phase3Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myelomarecruitingn=380
  • phase1A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myelomaactive not recruitingn=283
  • phase3A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)recruitingn=1,314
  • phase3Elranatamab/Lenalidomide Consolidation and/or Elranatamab Maintenance Versus Standard of Care After D-VRd Induction in Transplant-eligible NDMM Patientsrecruitingn=824
  • phase2Novel Combination Therapy in the Treatment of Relapsed and Refractory Aggressive B-Cell Lymphomaactive not recruitingn=129
  • phase2Comparing Lower Versus Standard Doses of Belantamab Mafodotin With Pomalidomide and Dexamethasone in Relapsed or Refractory Multiple Myeloma.not yet recruitingn=228
  • phase4An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.recruitingn=100
  • phase2A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myelomarecruitingn=200
more trials →

News(6)

  • Biogen's monoclonal antibody felzartamab wins first global approval in China
    Biogen’s monoclonal antibody felzartamab was approved in China for the treatment of multiple myeloma. Felzartamab will be available in China for second-line multiple myeloma patients alongside lena…
    endpoints · 4h ago
  • Bristol Myers wins ‘milestone’ FDA approval of myeloma drug acquired from Celgene
    The clearance of Zenbexus is the first for a group of protein-degrading “CELMoD” medicines that could help Bristol Myers rejuvenate a key drug franchise.
    biopharma_dive · 5h ago
  • STAT+: FDA approves Bristol multiple myeloma treatment, marking debut of novel drug class
    The FDA approved a treatment for advanced multiple myeloma made by Bristol Myers Squibb, marking the debut of a new class of drugs for the blood cancer.
    stat · 9h ago
  • BMS welcomes new multiple myeloma drug as generics batter current portfolio
    The FDA approves Zenbexus just as copycat competitors depress sales of Bristol Myers Squibb’s multiple myeloma drugs Pomalyst and Revlimid, which crashed 71% and 49% year-on-year, respectively, in…
    biospace · 9h ago
  • Dr Silbermann on Clinical Trial Design Considerations in Multiple Myeloma
    Rebecca Silbermann, MD, MMS, outlines key trial design considerations in multiple myeloma, including supportive care measures and end point selection.
    onclive · 3mo ago
  • FDA tests out ‘real-time’ clinical trials; AbbVie closes in on a KRAS biotech
    Through two pioneering studies, Amgen and AstraZeneca will share study data with FDA scientists as it’s accrued. Elsewhere, Lilly inked a gene editing deal and Pfizer reported success for a multipl…
    biopharma_dive · 3mo ago
brand
OZURDEX
trade names
Aeroseb-dex, Decaderm, Decadron, Decadron-75, Decaspray, Dexa-sine
generic
DEXAMETHASONE
MOA
12.1 Mechanism of Action Dexamethasone, a corticosteroid, has been shown to suppress inflammation by inhibiting multiple inflammatory cytokines resulting in decreased edema, fibrin deposition, capillary leakage and migration of inflammatory cells.
indication
1 INDICATIONS AND USAGE OZURDEX is a corticosteroid indicated for: The treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO) ( 1.1 ) The treatment of non-infectious uveitis affecting the posterior segment of the eye ( 1.2 ) The treatment of diabetic macular edema ( 1.3 ) 1.1 Retinal Vein Occlusion OZURDEX ® (dexamethasone intravitreal implant) is indicated for the treatment of macular edema following branch retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). 1.2 Posterior Segment Uveitis OZURDEX is indicated for the treatment of non-infectious uveitis affecting the posterior segment of the eye. 1.3 Diabetic Macular Edema OZURDEX is indicated for the treatment of diabetic macular edema.
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 21m ago
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