drug · small molecule

NUCYNTA

updated 3mo ago

by $COLL COLLEGIUM PHARMACEUTICAL, INC🔗 ChEMBL

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for 4 indications.

targets

Sodium-dependent noradrenaline transporterMu-type opioid receptor

all catalysts(0)

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brand

NUCYNTA

trade names

Nucynta, Nucynta er, Palexia

generic

TAPENTADOL HYDROCHLORIDE

MOA

12.1 MECHANISM OF ACTION Tapentadol is a centrally-acting synthetic analgesic. The exact mechanism of action is unknown. Although the clinical relevance is unclear, preclinical studies have shown that tapentadol is a mu-opioid receptor (MOR) agonist and a norepinephrine reuptake inhibitor (NRI). Analgesia in animal models is derived from both of these properties.

indication

1 INDICATIONS AND USAGE NUCYNTA (tapentadol) tablets are indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults and pediatric patients aged 6 years and older with a body weight of at least 40kg. NUCYNTA tablets are an opioid analgesic indicated for the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults and pediatric patients aged 6 years and older with a body weight of at least 40 kg. ( 1 ) Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration, and persist over the course of therapy, reserve opioid analgesics, including NUCYNTA tablets for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain. ( 1 , 5.1 ) Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dose or duration [see Warnings and Precautions (5.1) ] , and persist over the course of therapy, reserve opioid analgesics, including NUCYNTA tablets for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.

Data sources

ClinicalTrials.gov · OpenTargets

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drug · small molecule

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NUCYNTA

updated 3mo ago

by $COLL COLLEGIUM PHARMACEUTICAL, INC🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 6

Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for 4 indications.

targets

Sodium-dependent noradrenaline transporterMu-type opioid receptor

all catalysts(0)

nothing on the calendar yet

News(0)

no news has mentioned this drug yet

brand

NUCYNTA

trade names

Nucynta, Nucynta er, Palexia

generic

TAPENTADOL HYDROCHLORIDE

MOA

indication

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 9m ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

NUCYNTA

🐶 often sniffed alongside

targets

all catalysts(0)

News(0)

Report a data issue

comments(0)

NUCYNTA

🐶 often sniffed alongside

targets

all catalysts(0)

News(0)

Report a data issue

comments(0)