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drug · small molecule

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NICARDIPINE HYDROCHLORIDE

Marketedupdated 2mo ago

by $AMRX Amneal Pharmaceuticals, Inc.🔗 ChEMBL

Approved

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with an approval for hypertension and 3 investigational indications.

indications

investigational

Hypertension

targets

Voltage-gated L-type calcium channel

all catalysts(4)

approval · 4

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brand

NICARDIPINE HYDROCHLORIDE

trade names

Cardene, Cardene sr, Nicardipine hydrochloride

generic

NICARDIPINE HYDROCHLORIDE

MOA

Mechanism of Action Nicardipine hydrochloride capsules are a calcium entry blocker (slow channel blocker or calcium ion antagonist) that inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. The effects of nicardipine hydrochloride capsules are more selective to vascular smooth muscle than cardiac muscle. In animal models, Nicardipine hydrochloride capsules produce relaxation of coronary vascular smooth muscle at drug levels that cause little or no negative inotropic effect.

phase

marketed

NICARDIPINE HYDROCHLORIDE

indications

targets

all catalysts(4)

News(0)

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Patent cliff

patents (22)

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