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  1. pharmadog
  2. ›drugs
  3. ›MYQORZO
drug · small molecule
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MYQORZO

updated 5mo ago
by $CYTK CYTOKINETICS INC🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

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  • drugaficamten8 co-mentions · 2 sources
  • tagApproval8 co-mentions · 2 sources
  • tagSmall Molecule4 co-mentions · 2 sources

Small molecule drug with a maximum clinical stage of Preapproval (across all indications), with 2 investigational indications.

all catalysts(0)

nothing on the calendar yet

Trials studying MYQORZO

  • phase3A Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy (nHCM)active not recruitingn=500
  • phase3A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).active not recruitingn=65
  • phase3Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCMcompletedn=175
  • phase3Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic oHCMcompletedn=282
  • phase3Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCMenrolling by invitationn=900
  • phase3An Open-Label Study of Aficamten for Chinese Patients With Symptomatic oHCMcompletedn=40
  • phase1Study to Evaluate the Effect of Aficamten Administration on QT/QTc Intervalcompletedn=44

News(10)

  • ESC ‘26: Cytokinetics’ sell-off, Arrowhead’s edge and a heart drug autopsy
    At a big meeting for cardiovascular medicines, Cytokinetics and Arrowhead aimed to separate their drugs from competitors while a failed study pressured Alnylam.
    biopharma_dive · 29d ago
  • A winner, a loser, and a mid-stage signal from a major cardiology research conference
    The mental health system after Lindsay Clancy, pushing boundaries for new radiopharmaceuticals, and more health news from Morning Rounds
    stat · 29d ago
  • STAT+: Cytokinetics details trial win for what could be its next approval
    It took Cytokinetics 27 years to win its first drug approval. With the results of a new trial, its second could come much faster.
    stat · 1mo ago
  • #ESC26: Data in hand, Cytokinetics looks to expanded Myqorzo approval
    MUNICH — Cytokinetics’ heart drug Myqorzo could gain expanded approval next year, potentially doubling its market reach, after detailed results backed the drug’s use in a heart muscle disease. The…
    endpoints · 1mo ago
  • Capricor shares spike on CEO comments; Cytokinetics sues Bristol Myers
    The FDA is “willing to review” an updated submission for Capricor’s Duchenne cell therapy, its CEO said. Elsewhere, a heart drug battle spilled into court and Rigel priced the first “Protac” medicine.
    biopharma_dive · 1mo ago
  • Braveheart pumps more life into biotech IPO market with $382M expected debut
    Braveheart Bio has emerged on the Nasdaq with an upsized expected initial public offering—marking the public entrance of the twenty-second biotech this year.
    biospace · 1mo ago
  • Braveheart charges past expectations with $382.5M IPO to fund cardio drug from Hengrui
    Braveheart Bio has overcome its own IPO expectations, rallying $382.5 million in an upsized listing to fund its cardiovascular ambitions.
    fiercebiotech · 1mo ago
  • Attovia, Braveheart and Vogenx seek more than $500M across trio of IPOs
    Attovia Therapeutics, Braveheart Bio and Vogenx have set target ranges for their IPOs, positioning the trio to collectively net more than $500 million from public investors.
    fiercebiotech · 2mo ago
  • Braveheart, Attovia, Vogenx keep IPOs ballooning with plans to compete in cardiometabolic, immuno
    Braveheart Bio is looking to take on Bristol Myers Squibb in hypertrophic cardiomyopathy, while Attovia Therapeutics wants to challenge Sanofi and Regeneron’s Dupixent. Vogenx, meanwhile, is lookin…
    biospace · 2mo ago
  • Braveheart, Attovia join next wave of biotech IPOs
    The two startups are the third and fourth, respectively, to outline offerings this month and aim to capitalize on momentum that’s already yielded several big-ticket IPOs.
    biopharma_dive · 2mo ago
view all news mentions →
brand
MYQORZO
generic
AFICAMTEN
MOA
12.1 Mechanism of Action Aficamten is an allosteric and reversible inhibitor of cardiac myosin motor activity. Aficamten reduces the force generated by myosin at the cardiac sarcomere, which contributes to the pathophysiology of HCM. In patients with HCM, myosin inhibition with aficamten reduces cardiac contractility and left ventricular outflow tract (LVOT) obstruction.
indication
1 INDICATIONS AND USAGE MYQORZO is indicated for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to improve functional capacity and symptoms. MYQORZO is a cardiac myosin inhibitor indicated for the treatment of adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM) to improve functional capacity and symptoms. ( 1 )
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 1h ago
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