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  1. pharmadog
  2. ›drugs
  3. ›LYBALVI
drug · small molecule
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LYBALVI

updated 3mo ago
by $ALKS Alkermes plc.🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 8
  • tagApproval886 co-mentions · 299 sources
  • drugOLANZAPINE718 co-mentions · 300 sources
  • drugolanzapine ER718 co-mentions · 300 sources
  • drugolanzapine ODT444 co-mentions · 300 sources
  • tagSmall Molecule325 co-mentions · 239 sources
  • drugOLANZAPINE AND FLUOXETINE HYDROCHLORIDE180 co-mentions · 60 sources
  • drugolanzapine pamoate XR120 co-mentions · 30 sources
  • drugProzac120 co-mentions · 60 sources

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 7 approved and 27 investigational indications.

targets

D2-like dopamine receptor5-hydroxytryptamine receptor 2C5-hydroxytryptamine receptor 2A

all catalysts(0)

nothing on the calendar yet

Trials studying LYBALVI

  • phase3Study to Evaluate Efficacy and Safety of Roluperidone in Adult Subjects With Negative Symptoms and Stable Positive Symptoms of Schizophrenia and to Evaluate the Relapse Rate of Roluperidone and Antipsychotic Medicationsrecruitingn=380
  • phase3Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorderrecruitingn=220
  • phase1Open-label Trial Characterizing the PK of 3 SC Olanzapine Extended-release Formulations in Participants With Schizophrenia/Schizoaffective Disordercompletedn=106
  • phase1An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants With Schizophreniacompletedn=153
  • —A Study of Olanzapine in Participants With Bipolar Disorder.recruitingn=3,000
  • phase1Whole Blood and Plasma Sample Collection for the Development of Antipsychotic Immunoassays From Participants Taking Aripiprazole, Olanzapine, Paliperidone, or Risperidonecompletedn=81
  • phase1Safety, Tolerability, and Pharmacokinetic Study of TV-44749 in Chinese Patients With Schizophreniacompletedn=24
  • phase3A Study to Compare Disease Progression and Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics in Participant's With Recent-onset Schizophrenia or Schizophreniformcompletedn=337
more trials →

News(2)

  • As BMS’ Cobenfy struggles to gain traction, MapLight knocks on the door
    Despite the recent emergence of a new drug class, schizophrenia remains one of the most challenging neuropsychiatric diseases to treat—and Cobenfy's first steps into the market indicate there is st…
    biospace · 1d ago
  • 4 potential biotech M&A targets, plus a pretty sure bet from J&J
    Pharma is definitely interested in making more deals. But what biotechs will come under the magnifying glass? BioSpace takes a look at companies that analysts see as near-term targets for buyouts.
    biospace · 6d ago
brand
LYBALVI
trade names
Arkolamyl, Olansek, Olanzapine, Olanzapine apotex, Olanzapine cipla (previously olanzapine neopharma), Olanzapine component of lybalvi
generic
OLANZAPINE
MOA
12.1 Mechanism of Action The mechanism of action of olanzapine is unclear; however, its efficacy in the treatment of schizophrenia or bipolar I disorder could be mediated through a combination of dopamine and serotonin type 2 (5HT 2 ) antagonism. The mechanism of action of samidorphan could be mediated through opioid receptor antagonism.
indication
1 INDICATIONS AND USAGE LYBALVI is indicated for the treatment of: Schizophrenia in adults Bipolar I disorder in adults Acute treatment of manic or mixed episodes as monotherapy and as adjunct to lithium or valproate Maintenance monotherapy treatment LYBALVI is a combination of olanzapine, an atypical antipsychotic, and samidorphan, an opioid antagonist, indicated for the treatment of: Schizophrenia in adults ( 1 ) Bipolar I disorder in adults ( 1 ) Acute treatment of manic or mixed episodes as monotherapy and as adjunct to lithium or valproate Maintenance monotherapy treatment
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 30m ago
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