drug · protein

LUPKYNIS

updated 3mo ago

by $AUPH Aurinia Pharmaceuticals Inc.🔗 ChEMBL

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Protein drug with a maximum clinical stage of Approval (across all indications), with an approval for lupus nephritis and immune system disease and 9 investigational indications.

targets

Protein phosphatase 3 catalytic subunit alpha

all catalysts(0)

nothing on the calendar yet

Trials studying LUPKYNIS

phase3Voclosporin in Adolescent and Pediatric Subjects With Lupus Nephritisterminatedn=9
phase3Long-Term Voclosporin Treatment in Adolescent and Pediatric Subjects With Lupus Nephritisterminatedn=4
—LUPKYNIS Drug-use Results Surveyrecruitingn=400
—A Prospective Observational Registry of Patients Treated With LUPKYNIS® (Voclosporin) in the UScompletedn=229
phase2Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipientscompletedn=20
phase3A Study of QLG1074 Combined With Background Therapy in Subjects With Active Lupus Nephritisrecruitingn=270

News(2)

LifeMine raises $263M in mission to improve organ transplant aftercare
Patients who receive an organ transplant must take difficult immuno-suppressive medicines for the rest of their lives. LifeMine Therapeutics wants to offer a safer alternative.
biospace · 15d ago
‘Greg, you’ve got to bring back this platform’: How LifeMine won over Gates and Bezos for $188M series E
A little over a year ago, LifeMine Therapeutics laid off staff and put its fungus-based platform on ice to focus its dwindling resources on its lead asset. Now, the Massachusetts biotech is shaking…
fiercebiotech · 15d ago

brand

LUPKYNIS

trade names

Lupkynis

generic

VOCLOSPORIN

MOA

12.1 Mechanism of Action LUPKYNIS is a calcineurin-inhibitor immunosuppressant. The mechanism of voclosporin suppression of calcineurin has not been fully established. Activation of lymphocytes involves an increase in intracellular calcium concentrations that bind to the calcineurin regulatory site and activate calmodulin binding catalytic subunit and through dephosphorylation activates the transcription factor, Nuclear Factor of Activated T-Cell Cytoplasmic (NFATc). The immunosuppressant activity results in inhibition of lymphocyte proliferation, T-cell cytokine production, and expression of T-cell activation surface antigens. Studies in animal models also support a non-immunological role for calcineurin inhibition in kidney function to stabilize actin cytoskeleton and stress fibers in podocytes leading to increased podocyte integrity in glomeruli.

indication

1 INDICATIONS AND USAGE LUPKYNIS is indicated in combination with a background immunosuppressive therapy regimen [see Clinical Studies ( 14 )] for the treatment of adult patients with active lupus nephritis (LN). Limitations of Use: Safety and efficacy of LUPKYNIS have not been established in combination with cyclophosphamide. Use of LUPKYNIS is not recommended in this situation. LUPKYNIS is a calcineurin-inhibitor immunosuppressant indicated in combination with a background immunosuppressive therapy regimen for the treatment of adult patients with active lupus nephritis (LN). ( 1 , 14 ) Limitations of Use: Safety and efficacy of LUPKYNIS have not been established in combination with cyclophosphamide. Use of LUPKYNIS is not recommended in this situation.

Data sources

ClinicalTrials.gov · OpenTargets

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News(2)

LifeMine raises $263M in mission to improve organ transplant aftercare

Patients who receive an organ transplant must take difficult immuno-suppressive medicines for the rest of their lives. LifeMine Therapeutics wants to offer a safer alternative.

biospace · 15d ago

‘Greg, you’ve got to bring back this platform’: How LifeMine won over Gates and Bezos for $188M series E

A little over a year ago, LifeMine Therapeutics laid off staff and put its fungus-based platform on ice to focus its dwindling resources on its lead asset. Now, the Massachusetts biotech is shaking…

fiercebiotech · 15d ago

LUPKYNIS

🐶 often sniffed alongside

targets

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Trials studying LUPKYNIS

News(2)

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LUPKYNIS

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying LUPKYNIS

News(2)

Report a data issue

comments(0)