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  1. pharmadog
  2. ›drugs
  3. ›Breyanzi
drug · gene
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lisocabtagene maraleucel

Phase 2updated 5mo ago
by Bristol-Myers Squibb Co🔗 ChEMBL
Phase 2
community read0 votes

Gene drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 8 investigational indications.

indications

indications
DLBCL

targets

B-lymphocyte antigen CD19

all catalysts(0)

nothing on the calendar yet

Trials studying lisocabtagene maraleucel

  • phase2Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphomarecruitingn=20
  • phase3A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapyrecruitingn=400
  • phase1NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphomaactive not recruitingn=27
  • phase2Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)recruitingn=320
  • phase2Zanubrutinib and Lisocabtagene Maraleucel for the Treatment of Richter's Syndromerecruitingn=24
  • phase2Testing Drug Treatments After CAR T-cell Therapy in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphomarecruitingn=396
  • phase2Acalabrutinib + Liso-Cel In R/R Aggressive B-Cell Lymphomasactive not recruitingn=28
  • —Transgene Assay Testing Service of Tumor Samples From Patients Who Received a Bristol-Myers Squibb Manufactured Gene Modified Cell Therapy and Have a Qualifying Second Primary Malignancyrecruitingn=50

News(9)

  • Unlocking cell surface protein research with site-specific labeling
    Applications in flow cytometry, cell sorting, target validation, and therapeutic discovery
    biospace · 19d ago
  • Stripped of AstraZeneca safety net, BMS could face ‘carnage’ if high-risk clinical trial fails
    BMS is barreling toward a clinical trial readout that an H.C. Wainwright analyst believes could contribute to the return of mergers between mega-cap drugmakers.
    biospace · 1mo ago
  • UPDATED: Novartis halts autoimmune CAR-T trials after 3 deaths, as BMS also pauses studies
    Three deaths have forced Novartis to pause development of its CD19 CAR-T candidate in autoimmune diseases, just as Bristol Myers Squibb has halted a similar program due to immune-related adverse ev…
    fiercebiotech · 1mo ago
  • BMS ends Cellares pact over cell therapy production problems, triggering layoffs
    Setbacks to efforts to use Cellares’ automated platform to make an approved CAR-T cell therapy led BMS to terminate its partnership with the manufacturing specialist.
    biospace · 1mo ago
  • AstraZeneca scores in lung cancer; Sandoz inks a China deal
    A combination of AstraZeneca’s Tagrisso and Hutchmed’s Orpathys extended survival for some lung cancer patients. Elsewhere, MapLight floated the idea of partnering on its autism drug.
    biopharma_dive · 1mo ago
  • An AstraZeneca-Bristol Myers megamerger? Wall Street isn’t thrilled.
    In fact, the former lost tens of billions of dollars in market value following reports of a potential tie-up between the pharmaceutical giants.
    biopharma_dive · 2mo ago
  • Sanofi to ‘rebuild trust’ with Regeneron; Apnimed adds to string of ‘upsized’ biotech IPOs
    Sanofi wants to broaden the company’s productive partnership with Regeneron, its CEOs said. Elsewhere, Bristol Myers delayed two anticipated study readouts and a Shionogi-backed startup went public.
    biopharma_dive · 2mo ago
  • Lilly, AbbVie climb aboard in vivo CAR T train—but safety remains a hurdle
    Safety will be the key determinant of in vivo CAR T therapies, according to H.C. Wainwright’s Mitchel Kapoor, who noted that convenience and efficacy won’t be enough to impress investors in this sp…
    biospace · 2mo ago
  • Repligen strikes $1.5B BioLife buyout to bag cell therapy product pharmas rely on
    Top-selling cell therapies from BMS, J&J and Gilead depend on a BioLife product, positioning Repligen to use the takeover to increase its exposure to the modality.
    biospace · 2mo ago
brand
Breyanzi
generic
lisocabtagene maraleucel
MOA
B-lymphocyte antigen CD19 binding agent
indication
Chronic Lymphocytic Leukemia (CLL)
phase
phase_2
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 1h ago
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