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  1. pharmadog
  2. ›drugs
  3. ›Lerochol
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lerodalcibep

Marketedupdated 3mo ago
by LIB Therapeutics LLC
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • tagApproval4 co-mentions · 1 sources
  • drugLEROCHOL4 co-mentions · 1 sources
  • companyLIB Therapeutics LLC2 co-mentions · 1 sources

all catalysts(1)

approval · 1
Dec 12, 2025
approval
$TGTX49.16-1.21%
8mo ago
LEROCHOL (LERODALCIBEP-LIGA) — FDA approval
lerodalcibep
→

Trials studying lerodalcibep

  • phase3Study to Evaluate the Efficacy and Safety of Lerodalcibep in Children 6 to 17 Years, With Heterozygous FHenrolling by invitationn=150
  • phase3A Study on Efficacy and Safety of HST101 in Chinese Patients with Hypercholesterolemiarecruitingn=210
  • phase3Trial to Evaluate Efficacy and Safety of LIB003 and Inclisiran in High-risk CVD Patientscompletedn=166
  • phase3Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reductionenrolling by invitationn=2,000
  • phase3Study of Efficacy and Safety of LIB003 in Patient With CVD on Statins Requiring Additional LDL-C Reductionunknownn=900
  • phase3Study to Assess the Efficacy and Safety of LIB003 in HeFH Patients on Oral Lipid Therapy Needing Further LDL-C Reductioncompletedn=478
  • phase3Study of Long-Term Efficacy and Safety of LIB003 in CVD or High Risk for CVD Patients Needing Further LDL-C Reductionunknownn=900

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brand
Lerochol
generic
lerodalcibep-liga
MOA
12.1 Mechanism of Action Lerodalcibep-liga is a recombinant fusion protein that binds PCSK9 with picomolar affinity. PCSK9 binds to low-density lipoprotein receptor (LDLR) on the surface of hepatocytes to promote LDLR degradation within the liver. By inhibiting the binding of PCSK9 to LDLR, lerodalcibep-liga increases the number of LDLRs available to clear LDL-C from the blood, thereby lowering LDL-C levels. [see Clinical Pharmacology ( 12.3 )] .
indication
Homozygous Familial Hypercholesterolemia (HoFH)
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 48m ago
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