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  1. pharmadog
  2. ›drugs
  3. ›LEQVIO
drug · oligonucleotide
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LEQVIO

updated 5mo ago
by $NVS NOVARTIS AG🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 2
  • druginclisiran32 co-mentions · 8 sources
  • tagApproval32 co-mentions · 8 sources

Oligonucleotide drug with a maximum clinical stage of Approval (across all indications), with an approval for 3 indications.

targets

PCSK9 mRNA

all catalysts(0)

nothing on the calendar yet

Trials studying LEQVIO

  • phase4Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Interventionrecruitingn=6,000
  • phase2Phase 2 Clinical Study of MWX203 Injection Alone or in Combination With Inclisiran Sodium Injection in Patients With Mixed Dyslipidemiarecruitingn=216
  • phase3A Study of Inclisiran to Prevent Cardiovascular Events in High-risk Primary Prevention Patients.active not recruitingn=14,012
  • phase3Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Diseaseactive not recruitingn=17,004
  • phase3Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Eventsactive not recruitingn=608
  • phase4Study of Efficacy, Safety, Tolerability and Quality of Life of Inclisiran (KJX839) vs Placebo, on Top of Ongoing Individually Optimized Lipid-lowering Therapy, in Participants With Hypercholesterolemiacompletedn=1,770
  • phase2A Study to Evaluate the Safety, Efficacy of SYH2053 in Chinese Participants With Non-familial Hypercholesterolemia and Mixed Hyperlipidemiacompletedn=156
  • phase4Inclisiran Effectiveness in China: a Pragmatic Randomized Trialactive not recruitingn=1,590

News(7)

  • Novartis shareholder calls for board overhaul following costly deal setbacks: Reuters
    Novartis’ recent dual clinical setbacks have prompted questions from a major shareholder about the board’s oversight of dealmaking.
    fiercebiotech · 24d ago
  • Scribe’s early-stage IPO standout defies biotech’s derisking trend
    Scribe Therapeutics’ one-time epigenetic treatment is designed to slash the adherence burden of chronic cholesterol-lowering therapies while sidestepping the irreversibility of gene editing.
    biospace · 1mo ago
  • Scribe’s Benjamin Oakes on a rare IPO and bringing CRISPR to the masses
    The CEO spoke with BioPharma Dive about convincing investors to buy into the first gene editing IPO in more than two years.
    biopharma_dive · 1mo ago
  • Scribe records upsized $129M IPO to bankroll lipid-lowering genetic meds
    In vivo gene editing outfit Scribe Therapeutics has priced its IPO at $128.7 million, surpassing the $96 million goal set out earlier this week.
    fiercebiotech · 2mo ago
  • Novartis climbs on upbeat drug sales as key readouts loom
    A return to quarterly sales growth boosted shares higher on Tuesday, though a handful of coming study results will have a bigger impact on the company’s long-term outlook.
    biopharma_dive · 2mo ago
  • Scribe aims for $96M IPO to fund clinical push for lipid-lowering genetic meds
    Scribe Therapeutics has put its IPO plans down on paper, showing the genetic medicine company hopes to raise $96 million through its public listing.
    fiercebiotech · 2mo ago
  • Merck dives into cholesterol with first FDA approval for oral PCSK9 inhibitor
    Merck’s once-daily pill is the first oral PCSK9 inhibitor to hit the market for high cholesterol, beating AstraZeneca in the race to develop more accessible treatment options.
    biospace · 2mo ago
brand
LEQVIO
trade names
Leqvio
generic
INCLISIRAN SODIUM
MOA
12.1 Mechanism of Action Inclisiran is a double-stranded small interfering ribonucleic acid (siRNA), conjugated on the sense strand with triantennary N-Acetylgalactosamine (GalNAc) to facilitate uptake by hepatocytes. In hepatocytes, inclisiran utilizes the RNA interference mechanism and directs catalytic breakdown of mRNA for PCSK9. This increases LDL-C receptor recycling and expression on the hepatocyte cell surface, which increases LDL-C uptake and lowers LDL-C levels in the circulation.
indication
1 INDICATIONS AND USAGE LEQVIO ® is indicated as an adjunct to diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in: adults with hypercholesterolemia. adults and pediatric patients aged 12 years and older with heterozygous familial hypercholesterolemia (HeFH). pediatric patients aged 12 years and older with homozygous familial hypercholesterolemia (HoFH). LEQVIO is a small interfering RNA (siRNA) directed to proprotein convertase subtilisin kexin type 9 (PCSK9) mRNA indicated as an adjunct to diet and exercise to reduce low-density lipoprotein cholesterol (LDL-C) in: adults with hypercholesterolemia. ( 1 ) adults and pediatric patients aged 12 years and older with heterozygous familial hypercholesterolemia (HeFH). ( 1 ) pediatric patients aged 12 years and older with homozygous familial hypercholesterolemia (HoFH). ( 1 )
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 1h ago
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