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  1. pharmadog
  2. ›drugs
  3. ›Ebglyss
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lebrikizumab

Marketedupdated 3mo ago
by Lilly USA LLC
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • tagApproval12 co-mentions · 3 sources
  • drugEBGLYSS12 co-mentions · 3 sources
  • companyEli Lilly and Co6 co-mentions · 3 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with an approval for atopic eczema and eczematoid dermatitis and 5 investigational indications.

all catalysts(3)

approval · 3
Sep 13, 2024
approval
$LLY1180.16-2.25%
2y ago
EBGLYSS (LEBRIKIZUMAB-LBKZ) — FDA approval
lebrikizumab
→
May 22, 2025
approval
$LLY1180.16-2.25%
1y ago
EBGLYSS (LEBRIKIZUMAB-LBKZ) — FDA approval
lebrikizumab
→
Oct 28, 2025
approval
$LLY1180.16-2.25%
10mo ago
EBGLYSS (LEBRIKIZUMAB-LBKZ) — FDA approval
lebrikizumab
→

Trials studying lebrikizumab

  • phase1A Study of LAD106 in Healthy Adult Participantsrecruitingn=93
  • phase3Long-term Safety and Efficacy of Lebrikizumab in Adult and Adolescent Participant With Moderate-to-Severe Atopic Dermatitiscompletedn=174
  • phase3A Study of Lebrikizumab in Adults With Nummular Eczemanot yet recruitingn=270
  • phase3A Study of Lebrikizumab Treatment in Adults and Adolescents With Moderate-to-Severe Atopic Dermatitisactive not recruitingn=520
  • phase4A Study to See How Well Lebrikizumab Works in Adults and Adolescents With Moderate Atopic Dermatitis (Eczema) and High Itch Burdenrecruitingn=200
  • phase3A Study to Investigate the Efficacy and Safety of Lebrikizumab in Participants With Moderate-to-Severe Atopic Hand and Foot Dermatitisactive not recruitingn=206
  • phase3A Study of (LY3650150) Lebrikizumab to Assess the Safety and Efficacy of Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis and Skin of Colorcompletedn=90
  • phase3A Study of Lebrikizumab (LY3650150) in Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis Previously Treated With Dupilumabcompletedn=86
more trials →

News(1)

  • Chasing Dupixent, a biotech aims to make better antibody drugs for eczema
    Infinimmune, a California startup, is developing treatments it claims might last longer and be more effective than existing atopic dermatitis medications.
    biopharma_dive · 3d ago
brand
Ebglyss
generic
lebrikizumab
MOA
12.1 Mechanism of Action Lebrikizumab-lbkz is an IgG4 monoclonal antibody that binds with high affinity and slow off-rate to interleukin (IL)-13 and allows IL-13 to bind to IL-13Rα1 but inhibits human IL-13 signaling through the IL-4Rα/IL-13Rα1 receptor complex. IL-13 is a naturally occurring cytokine that is involved in Type 2 inflammation, which is an important component in the pathogenesis of atopic dermatitis. Lebrikizumab-lbkz inhibits IL-13-induced responses including the release of proinflammatory cytokines, chemokines and IgE. Lebrikizumab-lbkz-bound IL-13 can still bind IL-13Rα2 allowing subsequent internalization and natural clearance of IL-13.
indication
Atopic Dermatitis (Atopic Eczema)
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 27m ago
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