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  1. pharmadog
  2. ›drugs
  3. ›Ebglyss
drug
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lebrikizumab

Marketedupdated 5mo ago
by Lilly USA LLC
Approved
community read0 votes

🐶 often sniffed alongside

top 3
  • tagApproval12 co-mentions · 3 sources
  • drugEBGLYSS12 co-mentions · 3 sources
  • companyEli Lilly and Co6 co-mentions · 3 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with an approval for atopic eczema and eczematoid dermatitis and 5 investigational indications.

all catalysts(3)

approval · 3
Sep 13, 2024
approval
$LLY1142.85-0.61%
2y ago
EBGLYSS (LEBRIKIZUMAB-LBKZ) — FDA approval
lebrikizumab
→
May 22, 2025
approval
$LLY1142.85-0.61%
1y ago
EBGLYSS (LEBRIKIZUMAB-LBKZ) — FDA approval
lebrikizumab
→
Oct 28, 2025
approval
$LLY1142.85-0.61%
11mo ago
EBGLYSS (LEBRIKIZUMAB-LBKZ) — FDA approval
lebrikizumab
→

Trials studying lebrikizumab

  • phase2Efficacy and Speed of Response of Lebrikizumab in High-Burden Prurigo Nodularis Patientsnot yet recruitingn=15
  • phase1A Study of LAD106 in Healthy Adult Participantsrecruitingn=93
  • phase3Long-term Safety and Efficacy of Lebrikizumab in Adult and Adolescent Participant With Moderate-to-Severe Atopic Dermatitiscompletedn=174
  • phase3A Study of Lebrikizumab in Adults With Nummular Eczemanot yet recruitingn=270
  • phase3A Study of Lebrikizumab Treatment in Adults and Adolescents With Moderate-to-Severe Atopic Dermatitisactive not recruitingn=520
  • phase4A Study to See How Well Lebrikizumab Works in Adults and Adolescents With Moderate Atopic Dermatitis (Eczema) and High Itch Burdenrecruitingn=200
  • phase3A Study to Investigate the Efficacy and Safety of Lebrikizumab in Participants With Moderate-to-Severe Atopic Hand and Foot Dermatitisactive not recruitingn=206
  • phase3A Study of (LY3650150) Lebrikizumab to Assess the Safety and Efficacy of Adult and Adolescent Participants With Moderate-to-Severe Atopic Dermatitis and Skin of Colorcompletedn=90

News(4)

  • Pfizer’s eczema drug clears skin in mid-stage trial
    Detailed results are competitive with Dupixent and Ebglyss, but the drug lacks differentiation amid an increasingly competitive landscape, one analyst argued.
    biopharma_dive · 2d ago
  • 6 immunology targets to sustain a mammoth I&I market
    Johnson & Johnson, Pfizer, Argenx and more are unlocking new immunology targets and looking to improve on existing ones in an attempt to catch some of the magic brought about by AbbVie’s Humira and…
    biospace · 6d ago
  • North Immunology goes public via reverse merger as eczema drug heads toward clinic
    North Immunology has decided its path to taking an atopic dermatitis drug into the clinic involves going public via a reverse merger.
    fiercebiotech · 17d ago
  • Chasing Dupixent, a biotech aims to make better antibody drugs for eczema
    Infinimmune, a California startup, is developing treatments it claims might last longer and be more effective than existing atopic dermatitis medications.
    biopharma_dive · 1mo ago
brand
Ebglyss
generic
lebrikizumab
MOA
12.1 Mechanism of Action Lebrikizumab-lbkz is an IgG4 monoclonal antibody that binds with high affinity and slow off-rate to interleukin (IL)-13 and allows IL-13 to bind to IL-13Rα1 but inhibits human IL-13 signaling through the IL-4Rα/IL-13Rα1 receptor complex. IL-13 is a naturally occurring cytokine that is involved in Type 2 inflammation, which is an important component in the pathogenesis of atopic dermatitis. Lebrikizumab-lbkz inhibits IL-13-induced responses including the release of proinflammatory cytokines, chemokines and IgE. Lebrikizumab-lbkz-bound IL-13 can still bind IL-13Rα2 allowing subsequent internalization and natural clearance of IL-13.
indication
Atopic Dermatitis (Atopic Eczema)
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 4h ago
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