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  1. pharmadog
  2. ›drugs
  3. ›ELREXFIO
drug · antibody
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ELREXFIO

updated 3mo ago
by $PFE PFIZER INC🔗 ChEMBL
community read0 votes

🐶 often sniffed alongside

top 6
  • drugelranatamab29 co-mentions · 8 sources
  • tagApproval28 co-mentions · 7 sources
  • company$PFEPFIZER INC14 co-mentions · 7 sources
  • tagMultiple Myeloma3 co-mentions · 1 sources
  • companyCellCarta Biosciences Inc1 co-mentions · 1 sources
  • tagOncology1 co-mentions · 1 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with an approval for multiple myeloma and neoplasm and 2 investigational indications.

targets

T cell surface glycoprotein CD3Tumor necrosis factor receptor superfamily member 17

all catalysts(0)

nothing on the calendar yet

Trials studying ELREXFIO

  • phase2AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Multiple Myelomarecruitingn=226
  • phase1A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myelomaactive not recruitingn=59
  • phase2A Study of Elranatamab Outpatient Administration in Patients With Relapsed/Refractory Multiple Myelomarecruitingn=46
  • phase3Elranatamab/Lenalidomide Consolidation and/or Elranatamab Maintenance Versus Standard of Care After D-VRd Induction in Transplant-eligible NDMM Patientsrecruitingn=824
  • phase1A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/R MM)recruitingn=120
  • phase3MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)recruitingn=492
  • phase2Pre-transplant Purging and Post-transplant MRD-guided Maintenance Therapy With Elranatamab in Patients With High-risk Multiple Myelomarecruitingn=40
  • phase1A Study to Learn About the Effects of Cemsidomide in Combination With Elranatamab in Relapsed/Refractory Multiple Myeloma Subjectsrecruitingn=60
more trials →

News(4)

  • Regeneron ends eye disease trial for anti-CD3 antibody following safety review
    Regeneron has hit the brakes on the phase 1/2a trial for an experimental eye inflammation treatment, following an adverse event that tilted the drug’s risk/benefit profile in the wrong direction.
    fiercebiotech · 3d ago
  • CellCentric raises $220M for a ‘transformative’ multiple myeloma medicine
    A Series D round led by Venrock will support an ongoing Phase 2 study, and planned Phase 3 trial, of an oral drug the biotech sees as a differentiated option for patients with persistent disease.
    biopharma_dive · 3mo ago
  • Pfizer earns positive Phase 3 in multiple myeloma; ICON overstated revenue
    Pfizer’s positive Phase 3 data in multiple myeloma: The company’s Elrexfio produced a “statistically significant and clinically meaningful improvement” in progression-free survival in patients with…
    endpoints · 3mo ago
  • FDA tests out ‘real-time’ clinical trials; AbbVie closes in on a KRAS biotech
    Through two pioneering studies, Amgen and AstraZeneca will share study data with FDA scientists as it’s accrued. Elsewhere, Lilly inked a gene editing deal and Pfizer reported success for a multipl…
    biopharma_dive · 3mo ago
brand
ELREXFIO
trade names
Elrexfio
generic
ELRANATAMAB
MOA
12.1 Mechanism of Action Elranatamab-bcmm is a bispecific B-cell maturation antigen (BCMA)-directed T-cell engaging antibody that binds BCMA on plasma cells, plasmablasts, and multiple myeloma cells and CD3 on T-cells leading to cytolysis of the BCMA-expressing cells. Elranatamab-bcmm activated T-cells, caused proinflammatory cytokine release, and resulted in multiple myeloma cell lysis.
indication
1 INDICATIONS AND USAGE ELREXFIO is indicated for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy, including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. This indication is approved under accelerated approval based on response rate and durability of response [see Clinical Studies (14) ] . Continued approval for this indication may be contingent upon verification of clinical benefit in a confirmatory trial(s). ELREXFIO is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T‑cell engager indicated for the treatment of adult patients with relapsed or refractory multiple myeloma who have received at least four prior lines of therapy including a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody. This indication is approved under accelerated approval based on response rate and durability of response. Continued approval for this indication may be contingent upon verification of clinical benefit in a confirmatory trial(s). ( 1 )
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 34m ago
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