drug · small molecule

DUOPA

updated 5mo ago

by $ABBV AbbVie Inc.🔗 ChEMBL

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Small molecule drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 24 investigational indications.

targets

Aromatic-L-amino-acid decarboxylase

all catalysts(0)

nothing on the calendar yet

Trials studying DUOPA

phase3A Study to Evaluate the Efficacy and Safety of HRG2010 in Parkinson's Disease With Motor Fluctuationscompletedn=165
phase1A Study to Assess Effect of Dosing Intervals on Multiple-Dose Pharmacokinetics of WD-1603 Taken Before Meals in Healthy Participantsrecruitingn=12
—Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Diseaseactive not recruitingn=100
phase2Pharmacokinetics,Pharmacodynamics,Efficacy and Safety of HRG2010 in Parkinson's Disease Patients With Motor Fluctuationscompletedn=61
phase1A Safety, Tolerability, and Plasma Concentration Study of Levodopa/Carbidopa Subcutaneous Solution (ND0612) in Parkinson's Disease (PD) Patientscompletedn=8
phase2Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopacompletedn=20
phase1A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjectscompletedn=35
phase2Study To Assess The Clinical Benefit Of Droxidopa And Droxidopa/Carbidopa In Subjects With Fibromyalgiacompletedn=122

News(0)

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brand

DUOPA

trade names

Carbidopa, Carbidopa component of corbilta, Carbidopa component of crexont, Carbidopa component of dhivy, Carbidopa component of dopasnap, Carbidopa component of duopa

generic

CARBIDOPA

MOA

12.1 Mechanism of Action Carbidopa When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. Carbidopa inhibits the decarboxylation of peripheral levodopa, making more levodopa available for delivery to the brain. Levodopa Levodopa is the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. This is thought to be the mechanism whereby levodopa treats the symptoms of Parkinson's disease.

indication

1 INDICATIONS AND USAGE DUOPA ® is indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease. DUOPA is a combination of carbidopa (an aromatic amino acid decarboxylation inhibitor) and levodopa (an aromatic amino acid) indicated for the treatment of motor fluctuations in patients with advanced Parkinson’s disease ( 1 )

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 3h ago

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drug · small molecule

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DUOPA

updated 5mo ago

by $ABBV AbbVie Inc.🔗 ChEMBL

community read0 votes

🐶 often sniffed alongside

top 2

Small molecule drug with a maximum clinical stage of Approval (across all indications), with 4 approved and 24 investigational indications.

targets

Aromatic-L-amino-acid decarboxylase

all catalysts(0)

nothing on the calendar yet

Trials studying DUOPA

phase3A Study to Evaluate the Efficacy and Safety of HRG2010 in Parkinson's Disease With Motor Fluctuationscompletedn=165
phase1A Study to Assess Effect of Dosing Intervals on Multiple-Dose Pharmacokinetics of WD-1603 Taken Before Meals in Healthy Participantsrecruitingn=12
—Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Diseaseactive not recruitingn=100
phase2Pharmacokinetics,Pharmacodynamics,Efficacy and Safety of HRG2010 in Parkinson's Disease Patients With Motor Fluctuationscompletedn=61
phase1A Safety, Tolerability, and Plasma Concentration Study of Levodopa/Carbidopa Subcutaneous Solution (ND0612) in Parkinson's Disease (PD) Patientscompletedn=8
phase2Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopacompletedn=20
phase1A TQT Study to Evaluate the Electrocardiographic Effects of Carbidopa in Healthy Subjectscompletedn=35
phase2Study To Assess The Clinical Benefit Of Droxidopa And Droxidopa/Carbidopa In Subjects With Fibromyalgiacompletedn=122

News(0)

no news has mentioned this drug yet

brand

DUOPA

trade names

Carbidopa, Carbidopa component of corbilta, Carbidopa component of crexont, Carbidopa component of dhivy, Carbidopa component of dopasnap, Carbidopa component of duopa

generic

CARBIDOPA

MOA

indication

Data sources

ClinicalTrials.gov · OpenTargets

last refreshed 3h ago

Found something off?

comments(0)

5-min edit window · permanent after that

no comments yet — first sniff?

DUOPA

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying DUOPA

News(0)

Report a data issue

comments(0)

DUOPA

🐶 often sniffed alongside

targets

all catalysts(0)

Trials studying DUOPA

News(0)

Report a data issue

comments(0)