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  1. pharmadog
  2. ›drugs
  3. ›Datroway
drug · antibody drug conjugate
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datopotamab deruxtecan

pre_registrationupdated 5mo ago
by Daiichi Sankyo Co Ltd🔗 ChEMBL
community read0 votes

Antibody drug conjugate drug with a maximum clinical stage of Approval (across all indications), with 3 approved and 3 investigational indications.

indications

indications
NSCLC

targets

DNA topoisomerase 1Tumor-associated calcium signal transducer 2

all catalysts(0)

nothing on the calendar yet

Trials studying datopotamab deruxtecan

  • phase3Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterationsactive not recruitingn=740
  • phase2Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)recruitingn=454
  • phase1First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)active not recruitingn=890
  • phase2A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)recruitingn=46
  • phase2TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXdrecruitingn=357
  • phase2Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignanciesrecruitingn=695
  • phase4An Open-label, Single-arm Study of Prophylaxis for Datopotamab Deruxtecan (Dato-DXd) -Related Stomatitis in Eligible Patients With Metastatic or Inoperable Locally Recurrent Breast Cancer or Locally Advanced or Metastatic Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer.recruitingn=100
  • phase1Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Canceractive not recruitingn=155

News(10)

  • Summit partners with AstraZeneca and Daiichi; Eccogene earns $50M milestone
    Plus news about Regeneron. Summit Therapeutics to test cancer drug with Datroway: The biotech agreed to partner with AstraZeneca and Daiichi Sankyo on a clinical trial collaboration, testing its Tr…
    endpoints · 1d ago
  • AstraZeneca’s newly approved pill fails frontline breast cancer study
    Etcamah is the second oral “SERD” to recently fall short in first-line breast cancer, following a similar setback from Roche earlier this year.
    biopharma_dive · 19d ago
  • BioNTech sets survival standard in hard-to-treat cancer ahead of pivotal readout
    BioNTech has linked gotistobart to a median overall survival of 18.5 months in relapsed lung cancer patients, adding to evidence that the anti-CTLA-4 antibody is better than the standard of care.
    fiercebiotech · 22d ago
  • As portfolio erodes, BMS stands to gain a lot from rumored AstraZeneca merger
    While both drugmakers face looming patent cliffs, analysts say joining forces could help Bristol Myers Squibb replenish its eroding portfolio—while the strategic case for AstraZeneca seems to be mo…
    biospace · 2mo ago
  • ‘Unlikely’ AstraZeneca-BMS mega-merger would be largest pharma deal ever
    If AstraZeneca and Bristol Myers Squibb were to successfully become one company, analysts say it could reset the current deal environment, which has picked up greatly in the first half of the year.
    biospace · 2mo ago
  • Editor’s Corner: Why an AstraZeneca-Bristol Myers Squibb merger is a bad idea
    Combining the two drugmakers would trigger severe regulatory concerns and significant pipeline disruptions, cost numerous jobs, all while damaging the broader biopharma ecosystem and hurting patien…
    fiercebiotech · 2mo ago
  • Daiichi’s pipeline falls behind rivals as cash flow nears peak: analysts
    With Enhertu and Datroway hitting their peak revenue and rivals flowing into the antibody-drug conjugate space, Jefferies cuts expectations for Daiichi Sankyo.
    biospace · 2mo ago
  • Earnings roundup: Biogen’s ‘resiliency,’ AstraZeneca’s growth pitch and GSK’s oncology push
    Better-than-expected sales helped Biogen regain the support of investors, while AstraZeneca and GSK worked to convince Wall Street that they can hit ambitious revenue targets.
    biopharma_dive · 2mo ago
  • Merck posts—then pulls—trial plan for PD-1xVEGF and TROP2 ADC combination
    After keeping tight-lipped for nearly two years, Merck & Co. briefly dropped the first concrete hint as to where it intends to take its PD-1xVEGF bispecific antibody—before quietly scrubbing the ev…
    fiercebiotech · 2mo ago
  • AstraZeneca execs ‘very confident’ in homegrown ADC pipeline despite scrapping 2 candidates
    AstraZeneca executives told Fierce they are “very confident” in the pharma’s in-house pipeline of ADCs despite scrapping two candidates that underperformed in the clinic.
    fiercebiotech · 2mo ago
view all news mentions →
brand
Datroway
generic
datopotamab deruxtecan
MOA
DNA topoisomerase I inhibitor; Tumor-associated calcium signal transducer 2 binding agent
indication
Triple-Negative Breast Cancer (TNBC)
phase
pre_registration
Data sources
ClinicalTrials.gov · OpenTargets
last refreshed 1h ago
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