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  1. pharmadog
  2. ›drugs
  3. ›Praluent
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alirocumab

Marketedupdated 3mo ago
by Sanofi-Aventis US LLC
Approved
community read0 votes

🐶 often sniffed alongside

top 2
  • drugPRALUENT56 co-mentions · 14 sources
  • tagApproval56 co-mentions · 14 sources

Antibody drug with a maximum clinical stage of Approval (across all indications), with 6 approved and 6 investigational indications.

indications

investigational
Hyperlipidemia

all catalysts(14)

approval · 14
Jul 24, 2015
approval
$REGN803.48-0.31%
11y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Apr 24, 2017
approval
$REGN803.48-0.31%
9y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Jul 27, 2017
approval
$REGN803.48-0.31%
9y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Sep 20, 2017
approval
$REGN803.48-0.31%
9y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Jul 20, 2018
approval
$REGN803.48-0.31%
8y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Aug 22, 2018
approval
$REGN803.48-0.31%
8y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Nov 6, 2018
approval
$REGN803.48-0.31%
8y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Apr 26, 2019
approval
$REGN803.48-0.31%
7y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Apr 26, 2019
approval
$REGN803.48-0.31%
7y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Mar 10, 2020
approval
$REGN803.48-0.31%
6y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Apr 1, 2021
approval
$REGN803.48-0.31%
5y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Apr 1, 2021
approval
$REGN803.48-0.31%
5y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Mar 8, 2024
approval
$REGN803.48-0.31%
2y ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
Oct 9, 2025
approval
$REGN803.48-0.31%
10mo ago
PRALUENT (ALIROCUMAB) — FDA approval
alirocumab
→
view all 14 catalysts →

Trials studying alirocumab

  • phase2A Study to See How Safe and Effective Alirocumab is When Given Weekly to Adult Participants Who Have Hypercholesterolemiarecruitingn=420
  • —Alirocumab and Ischemic Risk in Atherosclerotic Cardiovascular Disease (ASCVD)active not recruitingn=2,214
  • phase2PCSK9 Inhibitor and PD-1 Inhibitor in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lungactive not recruitingn=60
  • phase2TOP 2301: Neoadjuvant Chemo for NSCLCsuspendedn=126
  • —Lipoprotein(a) Levels in Patients With Atherosclerotic Cardiovascular Diseases in Russiarecruitingn=2,382
  • phase1Alirocumab in Patients with Sepsiscompletedn=50
  • —Retrospective Analysis of the Effect of In-hospital Initiation of PCSK9i on Clinical Outcomes in Chinese ACS Patientsrecruitingn=10,000

News(5)

  • Merck dives into cholesterol with first FDA approval for oral PCSK9 inhibitor
    Merck’s once-daily pill is the first oral PCSK9 inhibitor to hit the market for high cholesterol, beating AstraZeneca in the race to develop more accessible treatment options.
    biospace · 29d ago
  • Gene editing developer Scribe plots an IPO
    The California drugmaker, which has collaborations in place with Biogen, Sanofi and Eli Lilly, could be the 14th biotech to go public in 2026.
    biopharma_dive · 1mo ago
  • Lilly tumbles on Foundayo’s shaky week; FDA to issue vouchers for psychedelics
    Lilly shares dipped, and Novo’s climbed, as Foundayo’s early trajectory diverged from that of oral Wegovy. Elsewhere, Regeneron inked a drug price deal and two companies announced leadership changes.
    biopharma_dive · 3mo ago
  • STAT+: Pharmalittle: We’re reading about a Trump deal with Regeneron, reclassifying medical marijuana, and more
    President Trump heralded a drug-pricing agreement with Regeneron, closing the last of 17 deals sought by the White House
    stat · 3mo ago
  • STAT+: Trump celebrates closing first round of drug pricing deals, promises more ahead
    A deal with Regeneron was the last of 17 initially sought by the White House.
    stat · 3mo ago
brand
Praluent
generic
alirocumab
MOA
12.1 Mechanism of Action Alirocumab is a human monoclonal antibody that binds to proprotein convertase subtilisin kexin type 9 (PCSK9). PCSK9 binds to the low-density lipoprotein (LDL) receptors (LDLR) on the surface of hepatocytes to promote LDLR degradation within the liver. By inhibiting the binding of PCSK9 to LDLR, alirocumab increases the number of LDLRs available to clear LDL, thereby lowering LDL-C levels.
indication
Heterozygous Familial Hypercholesterolemia (heFH)
phase
marketed
Data sources
openFDA · ClinicalTrials.gov
last refreshed 6m ago
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